Research

Please watch this great award-acceptance video higlighting some of the amazing unique research being conducted by the SPSC is on the Clinic page.

Patents (1)
  1. Power Rinse Inverted Sinus Rinse Bottle – Nasal Irrigation Device Patent USPTO Application #20110166523.
Active Projects (22)
  1. Blood transfusion requirements for endoscopic endonasal resection of sinonasal tumours. Retrospective chart review. Data collected, abstract submitted to two conferences and manuscript completed and ready for publication.
  2. The Efficacy of Endoscopic Sinus Surgery in the Management of Silent Sinus Syndrome. Retrospective chart review. Data collected abstract submitted to two conferences and first draft is currently being written.
  3. Leptospermum Honey Irrigation after Endoscopic Sinus Surgery. Randomized Control Trial (RCT) in progress.
  4. Cytokine Profiling in Chronic Rhinosinusitis Treated with Leptospermum Honey. RCT in progress.
  5. The Effect of Pulmicort Spray via Mucosal Atomization Device on the Hypothalamic-Pituitary Axis. RCT in progress.
  6. Balloon Dilatation for the Frontal Sinus Drainage Pathway in Patients With Chronic Rhinosinusitis: A Single Blinded Randomised Controlled Trial. RCT in progress.
  7. Medicated Punctured-Glove-Finger Spacer Study. RCT in progress.
  8. 15 Degree Reverse Trendelenburg Position for Functional Endoscopic Sinus Surgery (FESS). RCT in progress.
  9. Recurrence and recision rates in chronic rhinosinusitis with nasal polyposis. Retrospective chart review. Data collection in progress.
  10. Review of Olfaction in Patients Following Functional Endoscopic Sinus Surgery. Retrospective chart review. Data collection in progress.
  11. A comparison of two sphenoidotomy approaches on smell: superior turbinate intact vs. superior turbinate resection. Retrospective chart review. Data collected and currently writing initial draft.
  12. A Pilot, Open-label Study to Assess the Safety and Performance of the SinuSys Dilation System for Dilation of the Maxillary Sinus Ostium. Sponsor driven study. Currently waiting on REB to review project.
  13. Wang JCC, Hathorn I, Habib AR, Chang E, Javer AR. Evaluation of domestic and Yucatan swine nasal sinus anatomy as a model for future sino-nasal research. Data collection completed and manuscript has been submitted to the American Journal of Rhinology January 2012.
  14. Cytokine Profiling in Chronic Rhinosinusitis (CRS) Treated With Leptospermum Honey (LH)
  15. The Inter-Rater And Intra-Rater Reliability Of The Modified Philpott-Javer And Modified Lund-Kennedy Scoring Systems Following Sinus Surgery Based On Level Of Training
  16. The Optimal Head Position for Distributing Topical Nasal Medication using the Mucosal Atomization Device: A randomized, single-blind, parallel trial comparing the Lying-Head-Back versus the Head-Down-to-Floor positions
  17. Rates of MM synechia formation post-FESS: a double-blind randomized controlled trial comparing gloved merocel, silastic, and steroid-eluting MM spacers.
  18. The Efficacy Of A Thermosensitive Poloxamer 407-Based Topical Medication Regimen For Chronic Rhinosinusitis: A Retrospective Review
  19. The Inter-Rater And Intra-Rater Reliability Of The Boezaart And Alsaleh-Javer Scoring Systems During Sinus Surgery Based On Level Of Training.
  20. Antimicrobial Photodynamic Therapy For Treatment Of Refractory Chronic Rhinosinusitis: A Case Series
  21. Comparison of Ambulatory Surgical Centers to Hospital Based Facilities in Quality and Outcomes of Endoscopic Sinus Surgery
  22. The Safety Of Topical Intranasal Budesonide For Chronic Rhinosinusitis: A Cross-Sectional Study
Upcoming Studies (11)
  1. Determining the predictive value of the Bent and Kuhn Criteria in the diagnosis and disease progression of allergic fungal rhinosinusitis compared to a model including patient phenotype and genotype
  2. SinuSys Patency of Frontal Recess and Sphenoid Sinus Ostia Study
  3. Leptospermum Honey Irrigation after Endoscopic Sinus Surgery
  4. Effects of different concentrations of leptospermum honey in sinus irrigation solutions on pain sensation and ciliary immobilization
  5. Intranasal Retinoic Acid Treatment For Patients With Olfactory Loss: A Randomized Controlled Trial.
  6. The efficacy of debridement of the sinus cavity following primary functional endoscopic sinus surgery (FESS): A multicentre randomized controlled trial
  7. The Afars-Ship Study: An Investigator-Initiated Phase II Study To Evaluate The Efficacy And Safety Of AQX-1125 In Subjects With Chronic Allergic Fungal Rhinosinusitis (Afrs) Mediated By The SHIP1 Pathway.
  8. A Prospective Randomized Controlled Trial Assessing Medication Adherence Comparing Medication Tracking Diaries and Medication Mobile Applications in Otolaryngology
  9. A Prospective Randomized Controlled Trial Assessing the Need for Silastic Sheet Splints in Nasal Septal Repair Surgery
  10. Antimicrobial Photodynamic Therapy For Treatment Of Refractory Chronic Rhinosinusitis: A Randomised Controlled Trial
  11. The Efficacy Of A Thermosensitive Poloxamer 407-Based Topical Medication Regimen For Chronic Rhinosinusitis: A Randomised Controlled Trial
Refereed Publications (49)
  1. Javer, A., Wynne A. D., Borden J. H. and Judd G. J. R. Pine Oil: An oviposition deterrent for the onion maggot, Delia Antiqua(Meigen). Can. Ent. July 1987. 119: 605 – 609.
  2. Javer, A., Borden J. H., Pierce H. D. and Pierce A. M. Evaluation of Pheromone-baited traps for monitoring of Cucujid and Tenebrionid beetles in stored grain. J. Econ. Entomol. 1990. 83(1): 268 – 272.
  3. Javer, AR. and Schwarz, D. W. F. Plasticity in Human Directional Hearing. J Otolaryngol. 1995. 24(2): 111 – 117.
  4. Javer, AR., Stevens, H. E., Stillwell, M. and Jafar, A. M. Efficacy of Nuclear Scintigraphy in the Diagnosis and Management of Sinusitis. J. Otolaryngol. 1996. 25(6): 375-383.
  5. Javer, AR., Elliot, H. F. and Longridge, N. S. Hantavirus Infection: A possible cause of delayed Sensorineural Hearing Loss. Otolaryngol Head and Neck Surg. 1998 May; 118(5):697-701.
  6. Kuhn FA and Javer AR. Allergic Fungal Rhinosinusitis – our experience. Arch Otolaryngol Head Neck Surg. 124(10); Oct, 1998, 1179-80.
  7. Hurley DB, Javer AR, Kuhn FA, Citardi, MD. The endoscopic management of chronic frontal sinusitis associated with frontal sinus posterior table erosion. Am J Rhinol. 14;2: 113-120.
  8. Kuhn FA, Javer AR. Allergic Fungal Sinusitis: A four year follow-up. Am J Rhinol. 14:3: 149-156.
  9. Kuhn FA, Javer AR, Nagpal K, Citardi MJ: The frontal sinus rescue procedure: early experience and three-year follow-up. Am J Rhinol. 2000 Jul-Aug: 14(4):211-216.
  10. Ferguson BJ, Barnes L, Bernstein JM, Brown D, Clark CE 3rd, Cook PR, DeWitt WS, Graham SM, Gordon B, Javer AR, Krouse JH, Kuhn FA,
  11. Levine HL, Manning SC, Marple BF, Morgan AH, Osguthorpe JD, Skedros D, Rains BM 3rd, Ramadan HH, Terrell JE, Yonkers AJ. Geographic Variation in allergic fungal rhinosinusitis. Otol Clin North Am. 2000 Apr;33(2):441-449.
  12. Kuhn FA, Javer AR. Allergic fungal rhinosinusitis: perioperative management, prevention of recurrence and role of steroids and antifungal agents. Otolaryngol Clin North Am. 2000 Apr;33(2)419-433.
  13. Javer AR, Kuhn FA, Smith D. Stereotactic Computer Assisted Navigational Sinus Surgery: Accuracy of an Electromagnetic Tracking System with the Tissue Debrider and when Utilizing Different Headsets for the same patient. Am J Rhinol. 2000 Nov-Dec. 14(6):361-365.
  14. Javer AR, Kuhn FA. Stereotactic computer-assisted navigational sinus surgery: Historical perspective and review of available systems. J Otolaryngol. 2001 Feb. 30(1):60-64
  15. Kuhn FA, Javer AR. Primary Endoscopic Management of the Frontal Sinus. Otolaryngol Clin North Am. 2001 Feb;34(1)59-76.
  16. Citardi MJ, Javer AR, Kuhn FA. Revision Endoscopic Frontal Sinusotomy with Mucoperiosteal Flap Advancement: The Frontal Sinus Rescue Procedure. Otolaryngol Clin North Am. 2001 Feb;34(1)123-132.
  17. Javer AR, Sillers MJ, Kuhn FA. The frontal sinus unobliteration procedure. Otolaryngol Clin North Am. 2001 Feb;34(1)193-210.
  18. Kherani S, Javer AR, Woodham JW, Stevens HE. Comparison of an optical versus electromagnetic image guided system for endoscopic sinus surgery. J Otolaryngol. 2003 Aug. 32(4): 190-197.
  19. Kuhn FA, Javer AR. Low-Grade Fibrosarcoma of the Anterior Skull Base: Endoscopic Resection and Repair. Am J Rhinol. 2003 Nov-Dec. 17(6) 347-350.
  20. Herrmann BW, Citardi MJ, Vogler G, Gardner L, Smith G, Javer AR, Burt HM, Jackson J, Kuhn FA. A preliminary report on the effects of paclitaxel-impregnated stents on sheep nasal mucosa. Am J Rhinol. 2004 Mar-Apr;18(2):119-24.
  21. Chan KO, Tsaparas Y, Manarey C, Javer AR. Effectiveness of intraoperative mitomycin C in maintaining the patency of a frontal sinusotomy: a preliminary report of a double-blind randomized placebo-controlled trial.
  22. Am J Rhinol. 2006 May-Jun;20(3):295-9.
  23. Javer AR, Genoway K, Gervais M, Romney M, Zemcov J. Fungal Cultures in AFRS patients: improving the recovery of fungal pathogens in the Canadian Laboratory setting. J Otolaryngol. 2007 Feb;36(1):1-5.
  24. Javer AR, Genoway K. Patient quality of life improvements with and without computer assistance in sinus surgery. J Otolaryngol. 2006 Dec;35(6):373-9.
  25. Kuhn FA, Wong KK, Mechor B, Javer AR. How I Do It: Creating the “Double Curved” Suctions for Sinus Endoscopy and Surgery. Laryngoscope. Accepted for publication.
  26. Shoman N, Gheriani H, Flamer D, Javer A. Prospective, double-blind, randomized trial evaluating patient satisfaction, bleeding, and wound healing using biodegradable synthetic polyurethane foam (NasoPore) as a middle meatal spacer in functional endoscopic sinus surgery. J Otolaryngol Head Neck Surg. 2009 Feb;38(1):112-8.
  27. Chan KO, Genoway KA, Javer AR. Effectiveness of itraconazole in the management of refractory allergic fungal rhinosinusitis. J Otolaryngol Head Neck Surg. 2008 Dec;37(6):870-4.
  28. Mechor B, Javer AR. Revision endoscopic sinus surgery: the St. Paul’s Sinus Centre Experience. J Otolaryngol Head Neck Surg. 2008 Oct;37(5):676-80.
  29. Wong KK, Marglani O, Westerberg BD, Javer AR. Systemic absorption of topical gentamicin sinus irrigation. J Otolaryngol Head Neck Surg. 2008 Jun;37(3):395-8.
  30. Javer AR, Genoway K, Tsaparas Y. Comparison of swabs versus suction traps for endospcopically guided sinus cultures. J Otolaryngol Head Surg. 2008 Apr;37(2):185-91.
  31. Javer AR, Marglani O, Lee A, Matishak M, Genoway KA. Image-guided endoscopic transsphenoidal removal of pituitary tumors. J Otolaryngol Head Neck Surg. 2008 Aug;37(4):474-80.
  32. Gheriani H, Flamer D, Orton T, Mechor B, Javer A. A comparison of two sphenoidotomy approaches using a novel computerized tomography grading system. Am J Rhinol. 2008 Dec 4, [Epub ahead of print]
  33. Dickson JM, Zetler PJ, Walker B, Javer AR. Acanthamoeba rhinosinusitis. J Otolaryngol Head Neck Surg. 2009 Jun;38(3):E87-90.
  34. Javer AR, Gheriani H, Mechor B, Flamer D, Genoway K, Yunker WK. Effect of intraoperative injection of 0.25% bupivacaine with 1:200,000 epinephrine on intraoperative blood loss in FESS. Am J Rhinol Allergy. 2009 Jul-Aug;23(4):437-41.
  35. Javer AR, Alandejani T. Prevention and management of complications in frontal sinus surgery. Otolaryngol Clin North Am. 2010 Aug;43(4):827-38.
  36. Philpott CM, Thamboo A, Lai L, Park J, Javer AR. Endoscopic frontal sinusotomy – preventing recurrence or a route to revision? Laryngoscope. 2010 Aug;120(8):1682-6.
  37. Philpott CM, Dharmasi A, Witheford M, Javer AR. Endoscopic management of inverted papillomas: long-term results – the St. Paul’s Sinus Centre experience. Rhinology. 2010 Sep;48(3):358-63.
  38. Nabi S, Marglani OA, Javer AR. Mycobacterium Avium-Intracellulare Sinusitis. J Otolaryngol Head Neck Surg. 2010 Oct;39(5):E51-5.
  39. Philpott CM, Javer AR. Tumefactive fibroinflammatory lesion of the frontal sinus. J Laryngol Otol. 2010 Nov;124(11):1212-5.
  40. Desroisiers M, Evans GA, Keith PK, Wright ED, Kaplan A, Bouchard J, Ciavarella A, Doyle PW, Javer AR, Leith ES, Mukherji A, Schellenberg RR, Small P, Witterick IJ. Canadian clinical practice guidelines for acute and chronic rhinosinusitis. Allergy Asthma Clin Immunol. 2011 Feb 10;7(1):2.
  41. Wong D, Alandejani T, Javer AR. Evaluation of Manuka Honey in the management of allergic fungal rhinosinusitis. J Otolaryngol Head Neck Surg. 2011 Apr;40(2):E19-21.
  42. Desroisiers M, Evans GA, Keith PK, Wright ED, Kaplan A, Bouchard J, Ciavarella A, Doyle PW, Javer AR, Leith ES, Mukherji A, Schellenberg RR, Small P, Witterick IJ. Canadian clinical practice guidelines for acute and chronic rhinosinusitis. Executive summary. J Otolaryngol Head Neck Surg. 2011 May;40 Supp 2:S91-8.
  43. Desroisiers M, Evans GA, Keith PK, Wright ED, Kaplan A, Bouchard J, Ciavarella A, Doyle PW, Javer AR, Leith ES, Mukherji A, Schellenberg RR, Small P, Witterick IJ. Canadian clinical practice guidelines for acute and chronic rhinosinusitis. J Otolaryngol Head Neck Surg. 2011 May;40 Suppl 2:S99-193.
  44. Lau BC, Wong KK, Philpott CM, Alandejani T, Cheung VW, Javer AR. Cartilage on the floor: how effective is antibiotic sterilization? J Otolaryngol Head Neck Surg. 2011 Jun 1;40(3):221-5.
  45. Genoway KA, Philpott CM, Javer AR. Pathogen yield and antimicrobial resistance patterns of chronic rhinosinusitis patients presenting to a tertiary rhinology centre. J Otolaryngol Head Neck Surg. 2011 Jun 1;40(3):232-7.
  46. Thamboo A, Thamboo A, Philpott CM, Javer AR, Clark A. Single-blind study of manuka honey in allergic fungal rhinosinusitis. J Otolaryngol Head Neck Surg. 2011 Jun; 40(3):238-43.
  47. Philpott CM, Thamboo A, Lai L, Zheng G, Badri AV, Akbari A, Clark A, Javer AR. Olfactory dysfunction in allergic fungal rhinosinusitis. Arch Otolaryngol Head Neck Surg. 2011 Jul;137(7):694-7.
  48. Philpott CM, Javer AR, Clark A. Allergic fungal rhinosinusitis – a new staging system. Rhinology. 2011 Aug;49(3):318-23.
  49. Quon BS, Reid JD, Wong P, Wilcox PG, Javer AR, Wilson JM, Levy RD. Burkholderia gladioli – a predictor of poor outcome in cystic fibrosis patients who receive lung transplants? A case of locally invasive rhinosinusitis and persistent bacteremia in a 36 year-old lung transplant recipient with cystic fibrosis. Can Respir J. 2011 Jul;18(4):e64-5.
Non-Refereed Publications (9)
  1. Javer AR and Woodham JD. The Third Dimension – 3D Conservative Endoscopic Sinus Surgery. ENT News, February, 1999.
  2. Javer AR and Mechor BD. Allergic Fungal Rhinosinusitis: current perspectives. Journal of Allergy and Asthma, June 2007.
  3. Javer, AR and Kuhn FA. The Uniturbinate. Proceedings of the XXVI ISIAN and ERS, July, 1998.
  4. Kuhn F.A. and Javer AR. Endoscopic Management of Frontal Sinus Disease. Book Chapter. Ed: Wackym PA, Rice DH, Schaefer SD. Lippincott-Raven Publishers.
  5. Javer AR, Philpott C. Total Ethmoidectomy. Video Chapter 5. Ed: Kennedy D, Hwang P. Narrated by Dr .David Kennedy. Rhinology: Diseases of the Nose, Sinuses and Skull Base.
  6. Javer AR, Philpott C. Sphenopalatine Artery Ligation. Video Chapter 10. Ed: Kenned D, Hwang P. Rhinology: Diseases of the Nose, Sinuses and Skull Base.
  7. Javer AR. Chapter 8: Canadian Guidelines on Acute Sinusits.
  8. Javer AR, Alandejani T. Complications in Frontal Sinus Surgery. Chapter in Otolaryngology Clinics of North America. September, 2010
  9. Javer AR, Sunkareneni S. Video Chapter. Ed. David Kennedy
Research Papers (66)

The following is a list of research papers which can be opened up and reviewed in full with any PDF viewer application.

  1. A comparison of two sphenoidotomy approaches using a novel computerized tomography grading system
  2. A double-blind randomised controlled trial of gloved versus ungloved merocel middle meatal spacers for endoscopic sinus surgery
  3. A population-based study investigating chronic rhinosinusitis and the incidence of asthma
  4. A preliminary report on the effects of paclitaxel-impregnated stents on sheep nasal mucosa
  5. A Systematic Review of Factors Associated with Health-Related Quality of Life in Adolescents and Adults with Cystic Fibrosis
  6. Allergic fungal rhinosinusitis a new staging system
  7. Allergic fungal rhinosinusitis a new staging system
  8. Acanthamoeba rhinosinusitis
  9. Allergic Fungal Rhinosinusitis our experience
  10. Allergic fungal rhinosinusitis Perioperative management, prevention of recurrence, and role of steroids and antifungal agents
  11. Association between Chronic Rhinosinusitis and Health-Related Quality of Life in Adults with Cystic Fibrosis
  12. Blood transfusion requirements for endoscopic sinonasal inverted papilloma resections
  13. Burkholderia Gladioli-A Predictor of Poor Outcom
  14. Canadian clinical practice guidelines for acute and chronic rhinosinusitis
  15. Cartilage on the floor how effective is antibiotic sterilization
  16. Comparing the Reverse Trendelenburg and Horizontal Position for Endoscopic Sinus Surgery- A Randomized Controlled Trial
  17. Creating the Double Curved Suctions for Sinus Endoscopy and Surgery (1)
  18. Comparison of swabs versus suction traps for endoscopically guided sinus cultures
  19. Development of a tool for Global Rating of Endoscopic Surgical Skills (GRESS) for assessment of otolaryngology residents (1)
  20. Effect of intraoperative injection of 0.25% bupivacaine with 1-200,000 epinephrine on intraoperative blood loss in FESS
  21. Effectiveness of intraoperative mitomycin C in maintaining the patency of a frontal sinusotomy a preliminary report of a double-blind randomized placebo-controlled trial
  22. Effectiveness of itraconazole in the management of refractory allergic fungal rhinosinusitis
  23. Endoscopic management of inverted papillomas- long-term results the St. Pauls Sinus Centre experience
  24. Endoscopic frontal sinusotomy preventing recurrence or a route to revision
  25. Evaluation of domestic and Yucatan swine nasal sinus anatomy as models for future sinonasal research of medications delivered by standard instruments used in functional endoscopic sinus
  26. Evaluation of Manuka Honey in the Management of Allergic Fungal Rhinosinusitis
  27. Five-degree, 10-degree, and 20-degree reverse Trendelenburg position
  28. Fungal Cultures in AFRS patients improving the recovery of fungal pathogens in the Canadian Laboratory setting.
  29. Geographic variation in allergic fungal rhinosinusitis
  30. Hantavirus Infection- A possible cause of delayed Sensorineural Hearing Loss.
  31. Hemostatic effect of hot saline irrigation during functional endoscopic sinus surgery a randomized controlled trial
  32. Image-Guided Endoscopie Transsphenoidal Removal of Pituitary tumors
  33. International Consensus Statement on Allergy and Rhinology Rhinosinusitis
  34. Low-Grade Fibrosarcoma of the Anterior Skull Base- Endoscopic Resection and Repair
  35. Medical management of allergic fungal rhinosinusitis following endoscopic sinus surgery an evidence-based review and recommendations
  36. Mycobacterium Avium-Intracellulare Sinusitis
  37. Olfactory dysfunction in allergic fungal rhinosinusitis
  38. Omalizumab therapy for refractory allergic fungal rhinosinusitis patients with moderate or severe asthma
  39. Pathogen yield and antimicrobial resistance patterns of chronic rhinosinusitis patients presenting to a tertiary rhinology centre
  40. Patient quality of life improvements with and without computer assistance in sinus surgery
  41. Prevention and management of complications in frontal sinus surgery
  42. Primary Endoscopic Management of the Frontal Sinus
  43. Prospective, randomized trial evaluating patient satisfaction, bleeding, and wound healing using NasoPore as a middle meatal spacer in FESS
  44. Quality-of-life outcomes after sinus surgery in allergic fungal rhinosinusitis versus nonfungal chronic rhinosinusitis
  45. Randomized controlled trial hybrid technique using balloon dilation of the
  46. Rapid hemostasis in a sheep model using particles that propel thrombin and tranexamic acid
  47. Revision Endoscopic Frontal Sinusotomy with Mucoperiosteal Flap Advancement- The Frontal Sinus Rescue Procedure
  48. Revision endoscopic sinus surgery- the St. Pauls Sinus Centre Experience
  49. Single-Blind Study of Manuka Honey in Allergic Fungal
  50. Selecting the best approach to the frontal sinus
  51. Sinonasal methicillin-resistant Staphylococcus Aureus Updates on Treatment (2)
  52. Squeeze bottle versus saline spray after endoscopic sinus surgery for chronic rhinosinusitis a pilot multicentre trial.
  53. Stereotactic computer-assisted navigational sinus surgery- Historical perspective and review of available systems
  54. Stereotactic computer-assisted navigational sinus surgery- Historical perspective and review of the available systems
  55. Systemic absorption of topical gentamicin sinus irrigation
  56. The effect of head position on the distribution of topical nasal medication
  57. The effect of two sphenoidotomy approaches on the sense of smell- trans-ethmoidal versus trans-sphenoethmoidal
  58. The efficacy and safety of an office-based polypectomy with a vacuum=powered microdebrider
  59. The frontal sinus unobliteration procedure
  60. The interrater and intrarater reliability of the Philpott-Javer staging system based on level of training
  61. The safety and efficacy of short-term budesonide delivered via mucosal atomization device for chronic rhinosinusitis without nasal polyposis
  62. The safety and performance of a maxillary sinus ostium self-dilation device a pilot study
  63. The Sino-Nasal Outcome Test 22 as a tool to identify chronic rhinosinusitis in adults with CF
  64. Tumefactive fibroinflammatory lesion of the frontal sinus
  65. Validated assay for the simultaneous determination of cortisol and budesonide in human plasma using ultra high performance liquid chromatography tandem mass spectrometry
  66. Validation of a grading system for the attachment of the superior turbinate to the sphenoid face